17-ketosteroid and 17-hydroxycorticosteroid excretion in patients with duodenal ulceration.

The effect of intravenously-administered ACTH on plasma 17,21-dihydroxy-20-ketosteroids in normal individuals and in patients with disorders of the adrenal cortex.

The response of the adrenal cortex to exogenous ACTH has been recognized as one of the more specific and quantitative tests of adrenal function (1). Changes in the 24-hour excretion values of urinary 17-ketosteroids and 17-hydroxycorticosteroids during ACTH administration have proved to be valuable indices of adrenocortical capacity (2, 3). With the development of technics for the chemical esti...

Effect of Cortisone on 17-Ketosteroid Excretion *

In 1952 cortisone therapy was initiated in two patients with far advanced prostatic carcinoma.2 As part of the study of those patients, determinations were made of urinary 17-ketosteroid excretion before and during therapy with cortisone. Rather large increases in excretion of 17-ketosteroids were noted during the administration of high doses of cortisone in both patients. This unexpected findi...

The Excretion of Pregnanediol and 17-Ketosteroids during the Menstrual Cycle in Benign Hirsutism.

In 1949 Koets reported a variation in the urinary 1 7-ketosteroid excretion occurring during the menstrual cycle of women with benign hirsutism, the maximal excretion being at, or about, the presumed time of ovulation. It has been established that in normal women there is little or no cyclical fluctuation in the excretion of 17-ketosteroids (Werner, 1941; Patterson, McPhee, and Greenwood, 1942;...

Urinary excretion of 17-ketosteroids in children.

Determination of the urinary excretion of 1 7-ketosteroids (17-oxosteroids) is the most important laboratory test in the investigation of endocrine disorders involving the adrenal cortex and gonads in children. The normal range of excretion varies with the method employed, since non-steroidal pigment may to a greater or lesser degree be measured as 17-ketosteroid. It is important therefore to k...

17-Hydroxycorticosteroid and vanillylmandelic acid excretion in a rapidly cycling manic-depressive.